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Definition of breast cancer: Cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare.

Estimated new cases and deaths from breast cancer in the United States in 2008:


	New cases: 182,460 (female); 1,990 (male)

	Deaths: 40,480 (female); 450 (male)

Treatment

Information about treatment, including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy

Breast Cancer Treatment
[patient] [health professional]

Male Breast Cancer Treatment
[patient] [health professional]

Breast Cancer Treatment and Pregnancy
[patient] [health professional]

Clinical Trials to Treat Breast Cancer

Aromatase Inhibitors Come of Age

More...

Prevention, Genetics, Causes
Information related to prevention, genetics, risk factors

Breast Cancer Prevention
[patient] [health professional]

Genetics of Breast and Ovarian Cancer
[health professional]

Clinical Trials to Prevent Breast Cancer

Drop in Breast Cancer Rates Related to HRT Decline

Breast Cancer Risk Assessment Tool

Alcohol and Breast Cancer Risk: New Findings

More...

Screening and Testing
Information about methods of cancer detection including new imaging technologies, tumor markers, and biopsy procedures

Breast Cancer Screening
[patient] [health professional]

Clinical Trials to Screen for Breast Cancer

Annual Mammography Benefits Older Survivors

Computer Aid Reduces Accuracy of Mammograms

MRI Detects Cancers in the Opposite Breast

Get a Mammogram

More...

Clinical Trials
Information and current news about clinical trials and trial-related data

Breast Cancer Trial Results

Clinical Trials for Breast Cancer

How to Find a Cancer Treatment Trial

New Study of Targeted Therapies for Breast Cancer

The TAILORx Breast Cancer Trial

BreastCancerTrials.org: Patient-to-Trial Matching

Cancer Literature
Resources available from the PubMed database

Cancer Topic Searches: Breast Cancer

Cancer Topic Searches: Cancer Genetics

Cancer Literature in PubMed

Research and Related Information
Includes NCI-supported research, funding opportunities, and special reports

NCI Funded Research Portfolio

Breast SPOREs

Breast Cancer - NCI Office of Women's Health

Early Reproductive Events and Breast Cancer

Breast Cancer Progress Review Group Report

Breast Cancer Progress Report

Statistics
Information related to cancer incidence, mortality, and survival

Cancer Stat Fact Sheet: Cancer of the Breast

Snapshot of Breast Cancer

Probability of Breast Cancer in American Women

Finding Cancer Statistics

Understanding Cancer Statistics

Reference Links - Add a link

Overviews
- Breast Cancer(National Cancer Institute)
- Breast Cancer(Centers for Disease Control and Prevention)
- Detailed Guide: Breast Cancer(American Cancer Society)
Latest News
- Pregnancy HCG Levels Linked to Breast Cancer Risk(12/30/2008, Reuters Health)
- High Insulin Levels May Increase Breast Cancer Risk(12/30/2008, Reuters Health)
- Obesity Raises Risk of Cancer-Related Lymphedema(12/22/2008, Reuters Health)
- Breast Cancer Awareness(10/06/2008, Centers for Disease Control and Prevention)
- More News on Breast Cancer
Diagnosis/Symptoms
- Breast Awareness and Breast Self-Exam(National Women's Health Information Center)
- Breast Cancer: Early Detection(American Cancer Society)
- Breast Lumps - Biopsy(Patient Education Institute)
  Also available in Spanish
- Ductal Carcinoma In Situ(College of American Pathologists) - Links to PDF
- Invasive Ductal Carcinoma(College of American Pathologists) - Links to PDF
- Invasive Lobular Carcinoma(College of American Pathologists) - Links to PDF
- Lymphoscintigraphy(American College of Radiology, Radiological Society of North America)
  Also available in Spanish
- Needle Biopsy(Mayo Foundation for Medical Education and Research)
- Stages of Breast Cancer(Breastcancer.org)
- Stereotactic (Mammographically Guided) Breast Biopsy(American College of Radiology, Radiological Society of North America)
  Also available in Spanish
- Test Detects the Spread of Breast Cancer(Food and Drug Administration)
- Ultrasound-Guided Breast Biopsy(American College of Radiology, Radiological Society of North America)
  Also available in Spanish
- Understanding Breast Changes: A Health Guide for All Women(National Cancer Institute)
- Your Pathology Report (Breast Cancer)(Breastcancer.org)
  Also available in Spanish
Treatment
- Adjuvant Therapy for Breast Cancer: Questions and Answers(National Cancer Institute)
- Aromatase Inhibitors(National Cancer Institute)
- Breast Cancer (PDQ): Treatment(National Cancer Institute)
  Also available in Spanish
- Breast Cancer Treatment and Side Effects(Breastcancer.org)
- Herceptin (Trastuzumab): Questions and Answers(National Cancer Institute)
- MedlinePlus: Mastectomy(National Library of Medicine)
  Also available in Spanish
- Minimally Invasive Treatments for Breast Cancer(Society of Interventional Radiology)
- Radiation Therapy for Breast Cancer(American Society for Therapeutic Radiology and Oncology)
  Also available in Spanish
- Surgery Choices for Women with Early-Stage Breast Cancer(National Cancer Institute)
  Also available in Spanish
Prevention/Screening
- BRCA-1 and BRCA-2 Tests(American Association for Clinical Chemistry)
- Breast Cancer (PDQ): Prevention(National Cancer Institute)
- Breast Cancer (PDQ): Screening(National Cancer Institute)
- Environmental Factors and Breast Cancer Risk(National Institute of Environmental Health Sciences) - Links to PDF
- Estimating Breast Cancer Risk: Questions and Answers(National Cancer Institute)
- Medicines to Reduce Breast Cancer Risk(American Cancer Society)
- MedlinePlus: Mammography(National Library of Medicine)
  Also available in Spanish
- Preventive Mastectomy: Questions and Answers(National Cancer Institute)
- Prophylactic Oophorectomy: Preventing Cancer by Surgically Removing Your Ovaries(Mayo Foundation for Medical Education and Research)
- Protecting Your Health - Women Prescribed DES While Pregnant(Centers for Disease Control and Prevention)
- Test Determines Risk of Breast Cancer Returning(Food and Drug Administration)
Alternative Therapy
- Complementary and Holistic Medicine(Breastcancer.org)
Nutrition
- Nutrition and Breast Cancer(Breastcancer.org)
Coping
- For Women Facing a Breast Biopsy(American Cancer Society)
- Tips for Coping with Breast Cancer(American Cancer Society)
- When the Woman You Love Has Breast Cancer(Breast Cancer Network of Strength) - Large PDF file
  Also available in Spanish
Disease Management
- What Happens After Treatment for Breast Cancer?(American Cancer Society)
Specific Conditions
- Breast Cancer - Metaplastic(American Society of Clinical Oncology)
- DCIS - Ductal Carcinoma In Situ(Breastcancer.org)
- Inflammatory Breast Cancer(National Cancer Institute)
  Also available in Spanish
- Lobular Carcinoma In Situ(Mayo Foundation for Medical Education and Research)
- Paget�s Disease of the Nipple(National Cancer Institute)
- Recurrent and Metastatic Breast Cancer(Breastcancer.org)
- Types of Breast Cancer(Mayo Foundation for Medical Education and Research)
Related Issues
- Antiperspirants/Deodorants and Breast Cancer(National Cancer Institute)
  Also available in Spanish
- Breast Cancer and Pregnancy (PDQ)(National Cancer Institute)
  Also available in Spanish
- Breast Cancer and Your Job(Breastcancer.org)
- Breast Cancer Weight Gain(American Cancer Society)
- Can Having an Abortion Cause or Contribute to Breast Cancer?(American Cancer Society)
- Cancer Treatment for Women: Possible Sexual Side Effects(Mayo Foundation for Medical Education and Research)
- Fertility, Pregnancy, Adoption(Breastcancer.org)
- Hair, Skin, Nails, and Breast Cancer(Breastcancer.org)
- Known Health Effects for Women Prescribed DES (Diethylstilbestrol) While Pregnant(Centers for Disease Control and Prevention)
- Lymphedema: What Every Woman with Breast Cancer Should Know(American Cancer Society)
- Menopausal Hormone Use and Cancer(National Cancer Institute)
- Oral Contraceptives and Cancer Risk(National Cancer Institute)
  Also available in Spanish
- Pregnancy and Breast Cancer Risk(National Cancer Institute)
- Professional Help: Sexuality and Cancer(American Cancer Society)
- What Breast Cancer Survivors Need to Know about Osteoporosis(National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- What Causes Breast Cancer?(American Cancer Society)
Pictures & Photographs
- Pictures of Breast Cancer(Breastcancer.org)
Health Check Tools
- Breast Cancer Risk Questionnaire(Siteman Cancer Center)
  Also available in Spanish
- Breast Cancer Risk: Understanding the Puzzle(National Cancer Institute)
- Test Your Breast Cancer I.Q.(American Cancer Society)
Tutorials
- Breast Cancer(National Cancer Institute)
- Breast Cancer(Patient Education Institute)
  Also available in Spanish
- Breast Lumps - Biopsy(Patient Education Institute)
  Also available in Spanish
Videos
- Breast Cancer Treatment(OR-Live) - One hour program - 10/18/2007
- Multidisciplinary Treatment for Operable Breast Cancer(OR-Live) - One hour program
Anatomy/Physiology
- Atlas of the Body: The Breast -- Disorders(American Medical Association)
- Pictures of Breast Anatomy(Breastcancer.org)
- Understanding Cancer Series: Estrogen Receptors/SERMs(National Cancer Institute)
Financial Issues
- Insurance and Other Financial Issues Related to Breast Cancer Care(Susan G. Komen for the Cure)
Clinical Trials
- ClinicalTrials.gov: Breast Neoplasms(National Institutes of Health)
- ClinicalTrials.gov: Paget's Disease, Mammary(National Institutes of Health)
- Breast Cancer Prevention Studies(National Cancer Institute)
Genetics
- Genetic Testing for Breast and Ovarian Cancer Susceptibility(Centers for Disease Control and Prevention)
- Genetics Home Reference: Breast cancer(National Library of Medicine)
- Genetics Home Reference: Li-Fraumeni syndrome(National Library of Medicine)
- Genetics of Breast and Ovarian Cancer (PDQ)(National Cancer Institute)
- Learning about Breast Cancer(National Human Genome Research Institute)
Research
- Accelerated Breast Radiation: Cheaper, Faster, and Just As Effective?(American Cancer Society)
- Acupuncture May Help with Side Effects of Hormone Therapy(American Cancer Society)
- Anastrozole, Tamoxifen, and Bone Loss on the ATAC Trial(National Cancer Institute)
- Anthracyclines Improve Survival for HER2-Positive, But Not HER2-Negative, Breast Cancer(National Cancer Institute)
- Cancer Advances in Focus: Breast Cancer(National Cancer Institute)
- Cosmetic Results of Lumpectomy Impact Quality of Life(American Cancer Society)
- Dedicated Breast CT Scanner Offers Alternative to Mammography(National Institute of Biomedical Imaging and Bioengineering)
- Denosumab May Help Prevent Bone Loss Related to Use of Aromatase Inhibitors(National Cancer Institute)
- Factors Influencing Declines in Breast Cancer Mortality(National Cancer Institute)
- Faster Tumor Growth Rate Proof Younger Women Need Yearly Mammograms(American Cancer Society)
- Is Aspirin Linked to Lower Breast Cancer Risk?(American Cancer Society)
- New Drug Option for Late-Stage Breast Cancer Patients(American Cancer Society)
- New Studies on Anemia Drugs' Risks(Food and Drug Administration)
- New Targeted Fluorescent-Imaging Compound Allows Researchers to Detect Viable Cancer Cells in Mice(National Cancer Institute)
- Newly Identified Genetic Variations May Affect Breast Cancer Risk(National Cancer Institute)
- Osteoporosis Drug Raloxifene Does Not Protect against Coronary Heart Disease, but Reduces Breast Cancer Risk(National Cancer Institute)
- Outreach Programs Help African American Breast Cancer Patients(American Cancer Society)
- Paclitaxel Versus Docetaxel for Early Breast Cancer(National Cancer Institute)
- Shorter Course of Radiation Might Be Just As Effective with Early Breast Cancer(National Cancer Institute)
- Sister Study: A Study of the Environmental and Genetic Risk Factors for Breast Cancer(National Institute of Environmental Health Sciences)
- Study Quantifies Risk of Breast Cancer Recurrence(American Cancer Society)
- Study Sees Link Between Vitamin D, Breast Cancer Prognosis(American Cancer Society)
- Taxane Combinations Marginally Better Than Anthracyclines for Metastatic Breast Cancer(National Cancer Institute)
- Using Breast Density to Predict Breast Cancer Risk(American College of Physicians) - Links to PDF
- What�s New in Breast Cancer Research and Treatment?(American Cancer Society)
- Zoledronic Acid Improves Early Breast Cancer Treatment(National Cancer Institute)
Journal Articles
References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Take steps to protect your heart during cancer treatment. Women...
- Article: Effect of treatment with low-intensity and extremely low-frequency electrostatic fields...
- Article: What causes discrepancies in HER2 testing for breast cancer? A...
- Breast Cancer -- see more articles
- Genetics of Breast Cancer -- see more articles
- Paget's Disease of Breast -- see more articles
Dictionaries/Glossaries
- Deciphering Medspeak: Breast Cancer(Medical Library Association) - Links to PDF
- Dictionary of Cancer Terms(National Cancer Institute)
Directories
- ACOG's Physician Directory(American College of Obstetricians and Gynecologists)
- Find a Radiation Oncologist(American Society for Therapeutic Radiology and Oncology)
- Find an Oncologist(American Society of Clinical Oncology)
- National Breast and Cervical Cancer Early Detection Program Contacts(Centers for Disease Control and Prevention) - Directory of free or low-cost mammogram and Pap test programs
- Understanding Breast Changes: More Information(National Cancer Institute)
Organizations
- American Cancer Society
- Breast Cancer Network of Strength
  Also available in Spanish
- National Cancer Institute
Law and Policy
- Breast and Cervical Cancer Prevention and Treatment Act of 2000(Centers for Disease Control and Prevention)
- Women's Health and Cancer Rights Act(Centers for Medicare & Medicaid Services)
Statistics
- Breast Cancer Facts & Figures 2007-2008(American Cancer Society) - Large PDF file
- Breast Cancer Statistics(Centers for Disease Control and Prevention)
- Cancer of the Breast(National Cancer Institute)
Children
- Breast Cancer(Nemours Foundation)
  Also available in Spanish
Teenagers
- Is Breast Cancer a Threat in the Teen Years?(Nemours Foundation)
  Also available in Spanish
Men
- MedlinePlus: Male Breast Cancer(National Library of Medicine)
  Also available in Spanish
Seniors
- Breast Cancer(National Cancer Institute)

Clinical Trials - Add a clinical trial

top

Recruiting

A Breast Cancer Information Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer

Condition:

Breast Cancer

Interventions:

Procedure: informational intervention; Procedure: medical chart review; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment; Procedure: questionnaire administration; Procedure: study of socioeconomic and demographic variables; Procedure: survey administration

Recruiting

Anastrozole in Preventing Breast Cancer in Postmenopausal Women at Increased Risk of Breast Cancer

Condition:

Breast Cancer

Intervention:

Drug: anastrozole

Recruiting

A Study to Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Blood of Stage IV Breast Cancer Patients

Condition:

Breast Neoplasms

Interventions:

Other: Blood draw; Other: Blood draw

Recruiting

Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer

Condition:

Breast Cancer

Intervention:

Drug: letrozole

Recruiting

Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease

Condition:

Breast Cancer

Interventions:

Procedure: diagnostic laboratory biomarker analysis; Procedure: fine-needle aspiration; Procedure: immunohistochemistry staining method; Procedure: liquid chromatography; Procedure: mammography; Procedure: mass spectrometry; Procedure: needle biopsy; Procedure: protein analysis; Procedure: protein expression analysis; Procedure: proteomic profiling

Recruiting

Flaxseed in Preventing Breast Cancer in Premenopausal Women at Risk of Developing Breast Cancer

Conditions:

Breast Cancer; Precancerous/Nonmalignant Condition

Interventions:

Drug: flaxseed; Procedure: observation

Recruiting

Vaccine Therapy and Aldesleukin in Treating Women With Metastatic Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: aldesleukin; Drug: allogeneic large multivalent immunogen breast cancer vaccine; Procedure: flow cytometry; Procedure: immunoenzyme technique; Procedure: laboratory biomarker analysis

Recruiting

Changes in Breast Density and Breast Cancer Risk in Women With Breast Cancer and in Healthy Women

Condition:

Breast Cancer

Interventions:

Procedure: breast imaging study; Procedure: mammography; Procedure: physiologic testing; Procedure: screening questionnaire administration; Procedure: study of high risk factors

Recruiting

White Button Mushroom Extract in Preventing the Recurrence of Breast Cancer in Postmenopausal Breast Cancer Survivors

Condition:

Breast Cancer

Interventions:

Drug: white button mushroom extract; Procedure: flow cytometry; Procedure: high performance liquid chromatography; Procedure: laboratory biomarker analysis; Procedure: mass spectrometry; Procedure: pharmacogenomic studies; Procedure: pharmacological study

Recruiting

Simvastatin in Preventing a New Breast Cancer in Women Who Are at High Risk for a New Breast Cancer After Undergoing Surgery for Ductal Carcinoma in Situ or Stage I, Stage II, or Stage III Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: simvastatin; Procedure: laboratory biomarker analysis; Procedure: mammography; Procedure: pharmacological study

Recruiting

Trastuzumab, Cyclophosphamide, and an Allogeneic GM-CSF-Secreting Breast Tumor Vaccine for the Treatment of HER-2/Neu-Overexpressing Metastatic Breast Cancer

Condition:

Breast Neoplasms

Interventions:

Biological: Allogeneic GM-CSF-secreting breast cancer vaccine; Drug: Trastuzumab; Drug: Cyclophoshamide

Recruiting

Docetaxel Combined With Ketoconazole in Treatment of Breast Cancer

Condition:

Metastatic Breast Cancer

Intervention:

Drug: docetaxel

Recruiting

Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation

Conditions:

brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer; Hereditary Breast/Ovarian Cancer (brca1, brca2)

Interventions:

Drug: letrozole; Procedure: laboratory biomarker analysis; Procedure: pharmacogenomic studies

Recruiting

MPA Revisited: A Phase II Study of Anti-Metastatic, Anti-Angiogenic Therapy in Postmenopausal Patients With Hormone Receptor Negative Breast Cancer. A Translational Breast Cancer Research Consortium (TBCRC) Trial

Conditions:

Hormone Receptor Negative Breast Cancer; Locally Recurrent Breast Cancer; Metastatic Breast Cancer

Interventions:

Drug: Medroxyprogesterone progesterone acetate (MPA); Drug: Medroxyprogesterone Acetate with Cyclophosphamide plus Methotrexate

Recruiting

RCT Comparing Radioactive Seed Localization to Standard Procedure for Non-Palpable Breast Cancers

Conditions:

Invasive Breast Cancer; in Situ Breast Cancer

Intervention:

Procedure: radioguided seed localization for nonpalpable breast cancers

Recruiting

Exercise Intervention in Women With Metastatic Breast Cancer

Condition:

Breast Cancer

Intervention:

Behavioral: Moderate-Intensity Exercise

Recruiting

Thyroid Dysfunction in Women With Newly Diagnosed Stage I, Stage II, or Stage III Breast Cancer Who Are Planning to Undergo Chemotherapy Compared to Thyroid Dysfunction in Healthy Volunteers

Conditions:

Breast Cancer; Cancer-Related Problem/Condition; Fatigue

Interventions:

Procedure: fatigue assessment and management; Procedure: management of therapy complications; Procedure: physiologic testing

Recruiting

Trastuzumab, Cyclophosphamide, and Vaccine Therapy in Treating Patients With Metastatic Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: allogeneic GM-CSF-secreting breast cancer vaccine; Drug: cyclophosphamide; Drug: trastuzumab; Procedure: biopsy; Procedure: flow cytometry; Procedure: gene expression profiling; Procedure: immunoenzyme technique; Procedure: immunohistochemistry staining method; Procedure: immunologic technique

Recruiting

Adjuvant Chemotherapy in Treating Women Who Have Undergone Resection for Relapsed Breast Cancer

Condition:

Breast Cancer

Interventions:

Procedure: adjuvant therapy; Procedure: chemotherapy; Procedure: radiation therapy

Recruiting

CNF2024 (BIIB021) as Single-Agent Treatment in Subjects With HER2‑ Advanced Breast Cancer or in Combination With Trastuzumab in Subjects With HER2+ Advanced Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: CNF2024; Drug: CNF2024 + trastuzumab

Recruiting

Study of Anastrozole, Letrozole, or Exemestane With or Without Tamoxifen in Treating Postmenopausal Women With Hormone-Responsive Breast Cancer That Has Been Completely Removed By Surgery

Condition:

Breast Cancer

Interventions:

Drug: anastrozole; Drug: exemestane; Drug: letrozole; Drug: tamoxifen citrate; Procedure: adjuvant therapy

Not yet recruiting

Menopausal Symptoms in Women With Breast Cancer or At High Risk of Breast Cancer Treated on Another Clinical Trial

Conditions:

Breast Cancer; Cancer-Related Problem/Condition

Intervention:

Procedure: informational intervention

Recruiting

Combination Chemotherapy Followed By Docetaxel or Ixabepilone in Treating Patients Who Have Undergone Surgery for Nonmetastatic Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: cyclophosphamide; Drug: docetaxel; Drug: epirubicin hydrochloride; Drug: fluorouracil; Drug: ixabepilone; Drug: tamoxifen citrate; Procedure: adjuvant therapy; Procedure: aromatase inhibition therapy; Procedure: radiation therapy; Procedure: therapeutic conventional surgery

Recruiting

Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: letrozole; Drug: placebo

Recruiting

Quantitation of Endothelial Progenitor Cells as Markers of Tumor Angiogenesis in Breast Cancer

Conditions:

Breast Cancer Stage IV; Breast Cancer Stage I; Breast Cancer Stage II

Intervention:

Procedure: Blood Draw

Recruiting

Study of CR011-vcMMAE to Treat Locally Advanced or Metastatic Breast Cancer

Condition:

Breast Cancer

Intervention:

Drug: CR011-vcMMAE

Recruiting

Arimidex With Or Without Faslodex In Postmenopausal Women With HR Positive Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: Arimidex with Faslodex; Drug: Arimidex without Faslodex

Recruiting

A Phase II Study of Rapamycin and Trastuzumab for Patients With HER-2 Receptor Positive Metastatic Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: Rapamycin; Drug: Trastuzumab

Recruiting

Pre-Operative MRI in Young Breast Cancer Patients

Conditions:

Breast Cancer; Magnetic Resonance Imaging; Preoperative MRI

Intervention:

Procedure: Bilateral pre-operative MRI

Recruiting

Lapatinib in Metastatic Breast Cancer Resistant to Hormone Therapy

Condition:

Metastatic Breast Cancer

Intervention:

Drug: Lapatinib

Recruiting

Radiation Therapy in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer

Condition:

Breast Cancer

Intervention:

Procedure: radiation therapy

Recruiting

Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer

Condition:

Early-Stage Breast Cancer

Interventions:

Drug: genomically-guided treatment: Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC); Drug: non-genomically-guided treatment: Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC)

Recruiting

Atorvastatin in Preventing Breast Cancer in Women at Increased Risk for Breast Cancer

Conditions:

Breast Cancer; Precancerous/Nonmalignant Condition

Interventions:

Drug: atorvastatin calcium; Procedure: cytologic test; Procedure: fine-needle aspiration; Procedure: immunohistochemistry staining method; Procedure: laboratory biomarker analysis; Procedure: mass spectrometry; Procedure: polymerase chain reaction

Recruiting

Expressive Writing and Adjustment to Metastatic Breast Cancer

Condition:

Metastatic Breast Cancer

Interventions:

Behavioral: Writing Intervention; Behavioral: Writing Intervention

Recruiting

Phase II Trial of Doxil, Carboplatin, Bevacizumab in Triple Negative Untreated Metastatic Breast Cancer

Condition:

Metastatic Breast Cancer

Interventions:

Drug: Doxil; Drug: Carboplatin; Drug: Bevacizumab

Recruiting

Safety and Efficacy Study of the Trifunctional Antibody Ertumaxomab to Treat Patients With Advanced or Metastatic Breast Cancer

Conditions:

Breast Neoplasms; Breast Cancer

Intervention:

Drug: ertumaxomab

Recruiting

Exemestane in Preventing Cancer in Postmenopausal Women at Increased Risk of Developing Breast Cancer

Condition:

Breast Cancer

Intervention:

Drug: exemestane

Not yet recruiting

Letrozole in Treating Women With Primary Breast Cancer Who Have Received 5 Years of Aromatase Inhibitor Therapy

Condition:

Breast Cancer

Interventions:

Drug: letrozole; Drug: placebo

Recruiting

Therapy With Bevacizumab (BEV), Epirubicin, and Cyclophosphamide Followed by Docetaxel Plus Trastuzumab and BEV Given as Neoadjuvant or Adjuvant Therapy for Women With Locally Advanced HER2 Positive Invasive Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: Epirubicin; Drug: Cyclophosphamide; Drug: Docetaxel; Drug: Trastuzumab; Drug: Bevacizumab

Recruiting

Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer

Conditions:

Breast Cancer; Cancer of the Breast; Breast Neoplasm

Interventions:

Other: Letrozole (Femara); Drug: Letrozole; Avastin

Not yet recruiting

Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer

Condition:

Breast Cancer

Intervention:

Procedure: Prophylactic radiation to the contralateral breast

Recruiting

Phase III Study of Docetaxel + IMC-1121B or Placebo in Breast Cancer

Condition:

HER2 Negative Breast Cancer

Intervention:

Biological: IMCL-1121B

Recruiting

Fulvestrant With or Without Lapatinib and/or Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast Cancer That Progressed After Previous Aromatase Inhibitor Therapy

Condition:

Breast Cancer

Interventions:

Drug: anastrozole; Drug: exemestane; Drug: fulvestrant; Drug: lapatinib ditosylate; Drug: letrozole; Drug: placebo

Not yet recruiting

Study Evaluating Neratinib vs Lapatinib Plus Capecitabine for ErbB2 Positive Advanced Breast Cancer

Conditions:

Advanced Breast Cancer; Breast Cancer

Interventions:

Drug: Neratinib; Drug: Lapatinib plus Capecitabine

Recruiting

Capecitabine (Xeloda) and Lapatinib (Tykerb) as First-Line Therapy in HER2/Neu-Positive Breast Cancer

Conditions:

Breast Cancer; Metastatic Breast Cancer; Advanced Breast Cancer; HER2/Neu-Positive Breast Cancer

Interventions:

Drug: Capecitabine; Drug: Lapatinib

Recruiting

Serum Proteomics to Predict Gemcitabine Sensitivity in Breast Cancer

Condition:

Metastatic Breast Cancer

Intervention:

Drug: gemcitabine, carboplatin

Recruiting

Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: exemestane; Drug: tamoxifen citrate; Drug: triptorelin; Procedure: adjuvant therapy

Recruiting

Adjuvant Paclitaxel and Trastuzumab for Node-Negative HER2-Positive Breast Cancer

Conditions:

Breast Cancer; Carcinoma of the Breast

Interventions:

Drug: Paclitaxel; Drug: Trastuzumab

Recruiting

Green Tea Extract in Treating Women With Hormone Receptor-Negative Stage I, Stage II, or Stage III Breast Cancer

Condition:

Breast Cancer

Interventions:

Drug: defined green tea catechin extract; Procedure: biopsy; Procedure: gene expression analysis; Procedure: histopathologic examination; Procedure: immunoenzyme technique; Procedure: immunohistochemistry staining method; Procedure: immunologic technique; Procedure: laboratory biomarker analysis; Procedure: mammography; Procedure: mass spectrometry; Procedure: protein expression analysis; Procedure: quality-of-life assessment; Procedure: questionnaire administration

Recruiting

Pilot Study Comparing Hypnotherapy and Gabapentin for Hot Flashes in Breast Cancer Survivors

Conditions:

Breast Cancer; Hot Flashes

Interventions:

Behavioral: Hypnotherapy; Drug: gabapentin

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