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Breast Cancer

Clinical Trials  |  Add a link  |  Regulations  |  Discussion Board  |  Ask the Nurse | Last Update January 1st. 2009  |  About FDA.COM  | Media Kit

Definition of breast cancer: Cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare.

Estimated new cases and deaths from breast cancer in the United States in 2008:

 

 
New cases: 182,460 (female); 1,990 (male)
 
 
Deaths: 40,480 (female); 450 (male)
 
Treatment

Information about treatment, including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy
 

Breast Cancer Treatment
[patient] [health professional]

Male Breast Cancer Treatment
[patient] [health professional]

Breast Cancer Treatment and Pregnancy
[patient] [health professional]

Clinical Trials to Treat Breast Cancer

Aromatase Inhibitors Come of Age

More...
Prevention, Genetics, Causes
Information related to prevention, genetics, risk factors
 
Breast Cancer Prevention
[patient] [health professional]

Genetics of Breast and Ovarian Cancer
[health professional]

Clinical Trials to Prevent Breast Cancer

Drop in Breast Cancer Rates Related to HRT Decline

Breast Cancer Risk Assessment Tool

Alcohol and Breast Cancer Risk: New Findings

More...
Screening and Testing
Information about methods of cancer detection including new imaging technologies, tumor markers, and biopsy procedures
 
Breast Cancer Screening
[patient] [health professional]

Clinical Trials to Screen for Breast Cancer

Annual Mammography Benefits Older Survivors

Computer Aid Reduces Accuracy of Mammograms

MRI Detects Cancers in the Opposite Breast

Get a Mammogram

More...
  Clinical Trials
Information and current news about clinical trials and trial-related data
 
Breast Cancer Trial Results

Clinical Trials for Breast Cancer

How to Find a Cancer Treatment Trial

New Study of Targeted Therapies for Breast Cancer

The TAILORx Breast Cancer Trial

BreastCancerTrials.org: Patient-to-Trial Matching
 
Cancer Literature
Resources available from the PubMed database
 
Cancer Topic Searches: Breast Cancer

Cancer Topic Searches: Cancer Genetics

Cancer Literature in PubMed
 
Research and Related Information
Includes NCI-supported research, funding opportunities, and special reports
 
NCI Funded Research Portfolio

Breast SPOREs

Breast Cancer - NCI Office of Women's Health

Early Reproductive Events and Breast Cancer

Breast Cancer Progress Review Group Report

Breast Cancer Progress Report
 
Statistics
Information related to cancer incidence, mortality, and survival
 
Cancer Stat Fact Sheet: Cancer of the Breast

Snapshot of Breast Cancer

Probability of Breast Cancer in American Women

Finding Cancer Statistics

Understanding Cancer Statistics
 
 

Reference Links - Add a link

 

Clinical Trials - Add a clinical trial

 top
1
Recruiting
A Breast Cancer Information Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer
Condition:
Breast Cancer 
Interventions:
Procedure: informational intervention;   Procedure: medical chart review;   Procedure: psychosocial assessment and care;   Procedure: quality-of-life assessment;   Procedure: questionnaire administration;   Procedure: study of socioeconomic and demographic variables;   Procedure: survey administration 
 
 

 
2
Recruiting
Anastrozole in Preventing Breast Cancer in Postmenopausal Women at Increased Risk of Breast Cancer
Condition:
Breast Cancer 
Intervention:
Drug: anastrozole 
 
 

 
3
Recruiting
A Study to Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Blood of Stage IV Breast Cancer Patients
Condition:
Breast Neoplasms 
Interventions:
Other: Blood draw;   Other: Blood draw 
 
 

 
 
5
Recruiting
Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease
Condition:
Breast Cancer 
Interventions:
Procedure: diagnostic laboratory biomarker analysis;   Procedure: fine-needle aspiration;   Procedure: immunohistochemistry staining method;   Procedure: liquid chromatography;   Procedure: mammography;   Procedure: mass spectrometry;   Procedure: needle biopsy;   Procedure: protein analysis;   Procedure: protein expression analysis;   Procedure: proteomic profiling 
 
 

 
6
Recruiting
Flaxseed in Preventing Breast Cancer in Premenopausal Women at Risk of Developing Breast Cancer
Conditions:
Breast Cancer;   Precancerous/Nonmalignant Condition 
Interventions:
Drug: flaxseed;   Procedure: observation 
 
 

 
7
Recruiting
Vaccine Therapy and Aldesleukin in Treating Women With Metastatic Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: aldesleukin;   Drug: allogeneic large multivalent immunogen breast cancer vaccine;   Procedure: flow cytometry;   Procedure: immunoenzyme technique;   Procedure: laboratory biomarker analysis 
 
 

 
8
Recruiting
Changes in Breast Density and Breast Cancer Risk in Women With Breast Cancer and in Healthy Women
Condition:
Breast Cancer 
Interventions:
Procedure: breast imaging study;   Procedure: mammography;   Procedure: physiologic testing;   Procedure: screening questionnaire administration;   Procedure: study of high risk factors 
 
 

 
9
Recruiting
White Button Mushroom Extract in Preventing the Recurrence of Breast Cancer in Postmenopausal Breast Cancer Survivors
Condition:
Breast Cancer 
Interventions:
Drug: white button mushroom extract;   Procedure: flow cytometry;   Procedure: high performance liquid chromatography;   Procedure: laboratory biomarker analysis;   Procedure: mass spectrometry;   Procedure: pharmacogenomic studies;   Procedure: pharmacological study 
 
 

 
10
Recruiting
Simvastatin in Preventing a New Breast Cancer in Women Who Are at High Risk for a New Breast Cancer After Undergoing Surgery for Ductal Carcinoma in Situ or Stage I, Stage II, or Stage III Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: simvastatin;   Procedure: laboratory biomarker analysis;   Procedure: mammography;   Procedure: pharmacological study 
 
 

 
11
Recruiting
Trastuzumab, Cyclophosphamide, and an Allogeneic GM-CSF-Secreting Breast Tumor Vaccine for the Treatment of HER-2/Neu-Overexpressing Metastatic Breast Cancer
Condition:
Breast Neoplasms 
Interventions:
Biological: Allogeneic GM-CSF-secreting breast cancer vaccine;   Drug: Trastuzumab;   Drug: Cyclophoshamide 
 
 

 
12
Recruiting
Docetaxel Combined With Ketoconazole in Treatment of Breast Cancer
Condition:
Metastatic Breast Cancer 
Intervention:
Drug: docetaxel 
 
 

 
13
Recruiting
Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation
Conditions:
brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2) 
Interventions:
Drug: letrozole;   Procedure: laboratory biomarker analysis;   Procedure: pharmacogenomic studies 
 
 

 
14
Recruiting
MPA Revisited: A Phase II Study of Anti-Metastatic, Anti-Angiogenic Therapy in Postmenopausal Patients With Hormone Receptor Negative Breast Cancer. A Translational Breast Cancer Research Consortium (TBCRC) Trial
Conditions:
Hormone Receptor Negative Breast Cancer;   Locally Recurrent Breast Cancer;   Metastatic Breast Cancer 
Interventions:
Drug: Medroxyprogesterone progesterone acetate (MPA);   Drug: Medroxyprogesterone Acetate with Cyclophosphamide plus Methotrexate 
 
 

 
15
Recruiting
RCT Comparing Radioactive Seed Localization to Standard Procedure for Non-Palpable Breast Cancers
Conditions:
Invasive Breast Cancer;   in Situ Breast Cancer 
Intervention:
Procedure: radioguided seed localization for nonpalpable breast cancers 
 
 

 
16
Recruiting
Exercise Intervention in Women With Metastatic Breast Cancer
Condition:
Breast Cancer 
Intervention:
Behavioral: Moderate-Intensity Exercise 
 
 

 
17
Recruiting
Thyroid Dysfunction in Women With Newly Diagnosed Stage I, Stage II, or Stage III Breast Cancer Who Are Planning to Undergo Chemotherapy Compared to Thyroid Dysfunction in Healthy Volunteers
Conditions:
Breast Cancer;   Cancer-Related Problem/Condition;   Fatigue 
Interventions:
Procedure: fatigue assessment and management;   Procedure: management of therapy complications;   Procedure: physiologic testing 
 
 

 
18
Recruiting
Trastuzumab, Cyclophosphamide, and Vaccine Therapy in Treating Patients With Metastatic Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: allogeneic GM-CSF-secreting breast cancer vaccine;   Drug: cyclophosphamide;   Drug: trastuzumab;   Procedure: biopsy;   Procedure: flow cytometry;   Procedure: gene expression profiling;   Procedure: immunoenzyme technique;   Procedure: immunohistochemistry staining method;   Procedure: immunologic technique 
 
 

 
19
Recruiting
Adjuvant Chemotherapy in Treating Women Who Have Undergone Resection for Relapsed Breast Cancer
Condition:
Breast Cancer 
Interventions:
Procedure: adjuvant therapy;   Procedure: chemotherapy;   Procedure: radiation therapy 
 
 

 
20
Recruiting
 

 
21
Recruiting
Study of Anastrozole, Letrozole, or Exemestane With or Without Tamoxifen in Treating Postmenopausal Women With Hormone-Responsive Breast Cancer That Has Been Completely Removed By Surgery
Condition:
Breast Cancer 
Interventions:
Drug: anastrozole;   Drug: exemestane;   Drug: letrozole;   Drug: tamoxifen citrate;   Procedure: adjuvant therapy 
 
 

 
22
Not yet recruiting
Menopausal Symptoms in Women With Breast Cancer or At High Risk of Breast Cancer Treated on Another Clinical Trial
Conditions:
Breast Cancer;   Cancer-Related Problem/Condition 
Intervention:
Procedure: informational intervention 
 
 

 
23
Recruiting
Combination Chemotherapy Followed By Docetaxel or Ixabepilone in Treating Patients Who Have Undergone Surgery for Nonmetastatic Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: cyclophosphamide;   Drug: docetaxel;   Drug: epirubicin hydrochloride;   Drug: fluorouracil;   Drug: ixabepilone;   Drug: tamoxifen citrate;   Procedure: adjuvant therapy;   Procedure: aromatase inhibition therapy;   Procedure: radiation therapy;   Procedure: therapeutic conventional surgery 
 
 

 
24
Recruiting
Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: letrozole;   Drug: placebo 
 
 

 
25
Recruiting
Quantitation of Endothelial Progenitor Cells as Markers of Tumor Angiogenesis in Breast Cancer
Conditions:
Breast Cancer Stage IV;   Breast Cancer Stage I;   Breast Cancer Stage II 
Intervention:
Procedure: Blood Draw 
 
 

 
26
Recruiting
Study of CR011-vcMMAE to Treat Locally Advanced or Metastatic Breast Cancer
Condition:
Breast Cancer 
Intervention:
Drug: CR011-vcMMAE 
 
 

 
27
Recruiting
Arimidex With Or Without Faslodex In Postmenopausal Women With HR Positive Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: Arimidex with Faslodex;   Drug: Arimidex without Faslodex 
 
 

 
28
Recruiting
A Phase II Study of Rapamycin and Trastuzumab for Patients With HER-2 Receptor Positive Metastatic Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: Rapamycin;   Drug: Trastuzumab 
 
 

 
29
Recruiting
Pre-Operative MRI in Young Breast Cancer Patients
Conditions:
Breast Cancer;   Magnetic Resonance Imaging;   Preoperative MRI 
Intervention:
Procedure: Bilateral pre-operative MRI 
 
 

 
30
Recruiting
Lapatinib in Metastatic Breast Cancer Resistant to Hormone Therapy
Condition:
Metastatic Breast Cancer 
Intervention:
Drug: Lapatinib 
 
 

 
31
Recruiting
 

 
32
Recruiting
Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer
Condition:
Early-Stage Breast Cancer 
Interventions:
Drug: genomically-guided treatment: Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC);   Drug: non-genomically-guided treatment: Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC) 
 
 

 
33
Recruiting
Atorvastatin in Preventing Breast Cancer in Women at Increased Risk for Breast Cancer
Conditions:
Breast Cancer;   Precancerous/Nonmalignant Condition 
Interventions:
Drug: atorvastatin calcium;   Procedure: cytologic test;   Procedure: fine-needle aspiration;   Procedure: immunohistochemistry staining method;   Procedure: laboratory biomarker analysis;   Procedure: mass spectrometry;   Procedure: polymerase chain reaction 
 
 

 
34
Recruiting
Expressive Writing and Adjustment to Metastatic Breast Cancer
Condition:
Metastatic Breast Cancer 
Interventions:
Behavioral: Writing Intervention;   Behavioral: Writing Intervention 
 
 

 
35
Recruiting
Phase II Trial of Doxil, Carboplatin, Bevacizumab in Triple Negative Untreated Metastatic Breast Cancer
Condition:
Metastatic Breast Cancer 
Interventions:
Drug: Doxil;   Drug: Carboplatin;   Drug: Bevacizumab 
 
 

 
36
Recruiting
Safety and Efficacy Study of the Trifunctional Antibody Ertumaxomab to Treat Patients With Advanced or Metastatic Breast Cancer
Conditions:
Breast Neoplasms;   Breast Cancer 
Intervention:
Drug: ertumaxomab 
 
 

 
37
Recruiting
 

 
38
Not yet recruiting
Letrozole in Treating Women With Primary Breast Cancer Who Have Received 5 Years of Aromatase Inhibitor Therapy
Condition:
Breast Cancer 
Interventions:
Drug: letrozole;   Drug: placebo 
 
 

 
39
Recruiting
Therapy With Bevacizumab (BEV), Epirubicin, and Cyclophosphamide Followed by Docetaxel Plus Trastuzumab and BEV Given as Neoadjuvant or Adjuvant Therapy for Women With Locally Advanced HER2 Positive Invasive Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: Epirubicin;   Drug: Cyclophosphamide;   Drug: Docetaxel;   Drug: Trastuzumab;   Drug: Bevacizumab 
 
 

 
40
Recruiting
Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer
Conditions:
Breast Cancer;   Cancer of the Breast;   Breast Neoplasm 
Interventions:
Other: Letrozole (Femara);   Drug: Letrozole; Avastin 
 
 

 
41
Not yet recruiting
Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer
Condition:
Breast Cancer 
Intervention:
Procedure: Prophylactic radiation to the contralateral breast 
 
 

 
42
Recruiting
Phase III Study of Docetaxel + IMC-1121B or Placebo in Breast Cancer
Condition:
HER2 Negative Breast Cancer 
Intervention:
Biological: IMCL-1121B 
 
 

 
43
Recruiting
Fulvestrant With or Without Lapatinib and/or Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast Cancer That Progressed After Previous Aromatase Inhibitor Therapy
Condition:
Breast Cancer 
Interventions:
Drug: anastrozole;   Drug: exemestane;   Drug: fulvestrant;   Drug: lapatinib ditosylate;   Drug: letrozole;   Drug: placebo 
 
 

 
44
Not yet recruiting
Study Evaluating Neratinib vs Lapatinib Plus Capecitabine for ErbB2 Positive Advanced Breast Cancer
Conditions:
Advanced Breast Cancer;   Breast Cancer 
Interventions:
Drug: Neratinib;   Drug: Lapatinib plus Capecitabine 
 
 

 
45
Recruiting
Capecitabine (Xeloda) and Lapatinib (Tykerb) as First-Line Therapy in HER2/Neu-Positive Breast Cancer
Conditions:
Breast Cancer;   Metastatic Breast Cancer;   Advanced Breast Cancer;   HER2/Neu-Positive Breast Cancer 
Interventions:
Drug: Capecitabine;   Drug: Lapatinib 
 
 

 
46
Recruiting
Serum Proteomics to Predict Gemcitabine Sensitivity in Breast Cancer
Condition:
Metastatic Breast Cancer 
Intervention:
Drug: gemcitabine, carboplatin 
 
 

 
47
Recruiting
Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: exemestane;   Drug: tamoxifen citrate;   Drug: triptorelin;   Procedure: adjuvant therapy 
 
 

 
48
Recruiting
Adjuvant Paclitaxel and Trastuzumab for Node-Negative HER2-Positive Breast Cancer
Conditions:
Breast Cancer;   Carcinoma of the Breast 
Interventions:
Drug: Paclitaxel;   Drug: Trastuzumab 
 
 

 
49
Recruiting
Green Tea Extract in Treating Women With Hormone Receptor-Negative Stage I, Stage II, or Stage III Breast Cancer
Condition:
Breast Cancer 
Interventions:
Drug: defined green tea catechin extract;   Procedure: biopsy;   Procedure: gene expression analysis;   Procedure: histopathologic examination;   Procedure: immunoenzyme technique;   Procedure: immunohistochemistry staining method;   Procedure: immunologic technique;   Procedure: laboratory biomarker analysis;   Procedure: mammography;   Procedure: mass spectrometry;   Procedure: protein expression analysis;   Procedure: quality-of-life assessment;   Procedure: questionnaire administration 
 
 

 
50
Recruiting
Pilot Study Comparing Hypnotherapy and Gabapentin for Hot Flashes in Breast Cancer Survivors
Conditions:
Breast Cancer;   Hot Flashes 
Interventions:
Behavioral: Hypnotherapy;   Drug: gabapentin