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Heart Burn

Clinical Trials  |  Add a link  |  Regulations  |  Discussion Board  |  Ask the Nurse | Last Update January 1st. 2009  |  About FDA.COM  | Media Kit

What is heartburn?

Heartburn is a burning discomfort that is generally felt in the chest just behind the breastbone. The burning sensation results when harsh stomach juices come in contact with and irritate the delicate lining of the esophagus, the tube-like structure that connects the mouth to the stomach.

Why do stomach juices irritate the esophagus?

These juices, which are produced by the stomach to help the body break down food, contain a powerful acid called hydrochloric acid. While the stomach is naturally protected from this potent acid, the esophagus does not share the same protective qualities as the stomach. So, if acidic stomach contents come into contact with the esophagus, its skin-like lining can be irritated or injured and result in the sensation known as heartburn.

What causes heartburn?

Heartburn is caused when acidic stomach juices reflux — or flow backward — into the esophagus. This generally occurs when the lower esophageal sphincter (LES) — the natural valve that keeps stomach acid in the stomach and out of the esophagus — relaxes or is not functioning properly.

When functioning normally, the LES opens like a door that allows food into the stomach but not out the same way. However, at times the LES relaxes and allows stomach juices to flow upward into the esophagus. This relaxation exposes the esophagus to the harsh acid from the stomach. Physicians refer to this as gastroesophageal reflux.

 

 

Reference Links - Add a link

Clinical Trials - Add a clinical trial

 top
1
Recruiting
A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn
Condition:
Gastroesophageal Reflux 
Interventions:
Drug: Dexlansoprazole;   Drug: placebo 
 
 

 
 
3
Recruiting
PPI Versus Placebo in Severe Functional Heartburn
Condition:
GERD 
Intervention:
Drug: PPI 
 
 

 
 
5
Recruiting
Studying Genes for Barrett's Esophagus in Brothers and Sisters
Conditions:
Esophageal Cancer;   Precancerous/Nonmalignant Condition 
Interventions:
Procedure: comparative genomic hybridization;   Procedure: genetic linkage analysis;   Procedure: laboratory biomarker analysis;   Procedure: questionnaire administration;   Procedure: study of high risk factors 
 
 

 
6
Recruiting
Efficacy And Safety Of PF-00885706 For The Relief Of Symptoms In Subjects With Gastro-Esophageal Reflux Disease (GERD)
Condition:
Gastroesophageal Reflux Disease (GERD) 
Interventions:
Drug: PF-00885706;   Drug: PF-00885706;   Drug: PF-00885706;   Drug: PF-00885706;   Other: Placebo 
 
 

 
7
Recruiting
Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease
Condition:
Gastroesophageal Reflux Disease 
Interventions:
Behavioral: Questionnaires to evaluate QOL;   Behavioral: Questionnaires to evaluate heartburn and quality of life;   Behavioral: Questionnaire to evaluate satisfaction with treatment;   Behavioral: Questionnaire to evaluate presence or absence of pain 
 
 

 
8
Recruiting
Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis
Conditions:
Gastroparesis;   Gastroesophageal Reflux Disease 
Interventions:
Drug: Immediate-release omeprazole;   Drug: Delayed-release omeprazole 
 
 

 
9
Recruiting
What is the Optimal Duration for Reflux Studies?
Conditions:
Gastro-Esophageal Reflux Disease;   Functional Heartburn 
Intervention:
 
 
 

 
10
Recruiting
Compare How Effective Standard Dose Proton Pump Inhibitor (PPI) and Low Dose Tricyclic Antidepressant and Double Dose PPI to Standard Dose PPI and Placebo
Condition:
Gastroesophageal Reflux Disease 
Interventions:
Drug: Rabeprazole 20mg, placebo dinner and bedtime;   Drug: Rabeprazole 20 mg two times, Placebo at bedtime;   Drug: Rabeprazole 20mg,placebo dinner ,Low dose Tricyclic Antidepressant 
 
 

 
11
Recruiting
Elucidation of Acid-Induced Pulmonary Inflammation
Conditions:
Gastroesophageal Reflux;   Asthma 
Interventions:
Drug: lansoprazole;   Drug: placebo 
 
 

 
12
Recruiting
Outcomes After Esophagectomy With a Focus on Minimally Invasive Esophagectomy and Quality of Life
Conditions:
Esophagectomy;   Esophageal Cancer 
Intervention:
Procedure: Questionnaires 
 
 

 
13
Recruiting
Immunologic Factors in Reflux Esophagitis and Barrett’s Esophagus
Conditions:
Reflux Esophagitis;   Hiatal Hernia 
Intervention:
 
 
 

 
14
Recruiting
Study Using Esomeprazole as a Diagnostic Test for GERD in Patients With NCCP
Condition:
Gastroesophageal Reflux Disease 
Interventions:
Drug: esomeprazole;   Drug: Placebo 
 
 

 
15
Recruiting
Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain
Conditions:
Epigastric Pain;   Retrosternal Pain;   Esophagitis;   Gastrointestinal Symptoms 
Intervention:
 
 
 

 
 
 
18
Recruiting
 

 
19
Recruiting
ADX10059 as an Add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD)
Condition:
Gastroesophageal Reflux 
Interventions:
Drug: ADX10059;   Drug: ADX10059;   Drug: ADX10059;   Drug: ADX10059 Matching Placebo 
 
 

 
20
Recruiting
Demographics and Findings of Upper Endoscopy Patients
Conditions:
Barrett Esophagus;   Gastroesophageal Reflux 
Intervention:
 
 
 

 
21
Recruiting
Screening for Barrett's Esophagus in Otolaryngology Patients
Conditions:
Extra Esophageal Symptoms:;   Cough;   Throat Clearing;   Hoarseness;   Difficulty Swallowing 
Intervention:
Drug: Proton Pump Inhibitor 
 
 

 
22
Recruiting
Endoscopic Findings in Patients With Typical Gastroesophageal Reflux Disease (GERD) Symptoms
Condition:
Gastroesophageal Reflux Disease 
Intervention:
 
 
 

 
23
Recruiting
Evaluation of Patients With Non-Cardiac Chest Pain
Conditions:
Non-Cardiac Chest Pain;   Gastroesophageal Reflux Disease 
Intervention:
Procedure: Capsule endoscopy 
 
 

 
24
Recruiting
Exhaled Breath Condensate pH in Patients With Cough Caused by Gastroesophageal Reflux
Conditions:
Cough;   Gastroesophageal Reflux 
Intervention:
Device: RTube Exhaled Breath Condensate Collection System 
 
 

 
25
Recruiting
The Use of Proton Pump Inhibitor for the Treatment of Non-Erosive Gastro-Oesophageal Reflux Disease in Chinese Population
Condition:
Gastroesophageal Reflux 
Intervention:
Drug: Esomeprazole 20mg once daily 
 
 

 
26
Recruiting
Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS)
Conditions:
Erosive Gastroesophageal Reflux Disease;   Non-Erosive Reflux Disease 
Intervention:
Drug: Pantoprazole 
 
 

 
27
Recruiting
 

 
28
Recruiting
Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression
Conditions:
Exercise Triggered Asthma;   Gastroesophageal Reflux 
Interventions:
Drug: Nexium;   Drug: Placebo 
 
 

 
29
Not yet recruiting
 

 
30
Recruiting
Nexium 40mg Once Daily Vs Prevacid 30mg Twice a Day for Control of Severe GERD
Condition:
GERD 
Intervention:
Drug: Antacids 
 
 

 
31
Recruiting
Study to Identify Non-Invasive Markers of Gastrointestinal Allergy
Conditions:
Esophagitis;   Colitis 
Intervention:
 
 
 

 
32
Recruiting
Effects of Hoodia on Blood Pressure and Heart Function
Condition:
Healthy 
Interventions:
Dietary Supplement: Hoodia Gordonii;   Dietary Supplement: Placebo 
 
 

 
33
Not yet recruiting
Adult Stem Cell Response to Burn Injury
Conditions:
Wound Healing;   Burn 
Intervention:
 
 
 

 
34
Recruiting
Dexmedetomidine Cardiovascular Safety in Pediatric Burn Patients
Conditions:
Burns;   Sedation 
Intervention:
Drug: Dexmedetomidine 
 
 

 
35
Recruiting
Randomized Trial of Two Ablation Catheters in Paroxysmal Atrial Fibrillation
Condition:
Atrial Fibrillation 
Interventions:
Procedure: WACA and PVI;   Procedure: PVAC 
 
 

 
36
Recruiting
Low-Dose Hydrocortisone in Acutely Burned Patients
Condition:
Burns 
Intervention:
Drug: hydrocortisone 200 mg/day 
 
 

 
37
Recruiting
Efficacy of Different Ablation Strategies for Controlling Atrial Fibrillation
Condition:
Atrial Fibrillation 
Intervention:
Procedure: Radiofrequency ablation 
 
 

 
38
Recruiting
 

 
39
Recruiting
"Improving Diet, Exercise And Lifestyle (IDEAL) for Women" Study
Conditions:
Overweight;   Obesity 
Interventions:
Behavioral: Exercise - Aerobic and Resistance;   Behavioral: Dietary - Caloric Restriction 
 
 

 
40
Not yet recruiting
Transfusion-Associated Microchimerism in Previously Injured Individuals Who Received a Blood Transfusion
Conditions:
Chimerism;   Blood Transfusion;   Wounds and Injuries 
Intervention:
 
 
 

 
41
Not yet recruiting
Bacterial Infection Diagnosis Using Blood DNA
Conditions:
Infection;   Sepsis 
Intervention:
Other: Observational study 
 
 

 
42
Recruiting
Body Weight Regulation in Patients With Narcolepsy
Condition:
Narcolepsy 
Intervention:
 
 
 

 
43
Recruiting
Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity
Conditions:
Obesity;   Chronic Sleep Deprivation 
Intervention:
Procedure: Increase sleep 
 
 

 
44
Not yet recruiting
Infliximab Plus Intravenous Immunoglobulin for the Primary Treatment of Kawasaki Disease
Condition:
Kawasaki Disease 
Interventions:
Drug: Infliximab;   Drug: Placebo 
 
 

 
45
Recruiting
Comparison of Rituxan Versus Bexxar When Combined With Carmustine, Etoposide, Cytarabine and Melphalan (BEAM) With Autologous Hematopoietic Stem Cell Transplantation (ASCT)
Conditions:
Lymphoma, B-Cell;   Lymphoma, Large-Cell, Immunoblastic;   Lymphoma, Non-Hodgkin 
Interventions:
Drug: Autologous transplantation using rituxan/BEAM;   Drug: Autologous transplantation using Bexxar/BEAM