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Migraines

Clinical Trials  |  Add a link  |  Regulations  |  Discussion Board  |  Ask the Nurse | Last Update January 1st. 2009  |  About FDA.COM  | Media Kit

A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit.

Migraine is three times more common in women than in men. Some people can tell when they are about to have a migraine because they see flashing lights or zigzag lines or they temporarily lose their vision.

Many things can trigger a migraine. These include

  • Anxiety
  • Stress
  • Lack of food or sleep
  • Exposure to light
  • Hormonal changes (in women)

Doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. Now they believe the cause is related to genes that control the activity of some brain cells. Medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. For many people, treatments to relieve stress can also help.


What is Migraine?

The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. It is often accompanied by extreme sensitivity to light and sound, nausea, and vomiting. Migraine is three times more common in women than in men. Some individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a lack of food or sleep, exposure to light, or hormonal irregularities (only in women). Anxiety, stress, or relaxation after stress can also be triggers. For many years, scientists believed that migraines were linked to the dilation and constriction of blood vessels in the head. Investigators now believe that migraine is caused by inherited abnormalities in genes that control the activities of certain cell populations in the brain.

Is there any treatment?

There are two ways to approach the treatment of migraine headache with drugs: prevent the attacks, or relieve the symptoms during the attacks. Many people with migraine use both approaches by taking medications originally developed for epilepsy and depression to prevent future attacks, and treating attacks when they happen with drugs called triptans that relieve pain and restore function. Hormone therapy may help some women whose migraines seem to be linked to their menstrual cycle. Stress management strategies, such as exercise, relaxation, biofeedback, and other therapies designed to help limit discomfort, may also reduce the occurrence and severity of migraine attacks.

 

What is the prognosis?

Taking a combination of drugs to prevent and treat migraine attacks when they happen helps most people with migraine to limit the disabling effects of these headaches. Women whose migraine attacks occur in association with their menstrual cycle are likely to have fewer attacks and milder symptoms after menopause.

 

What research is being done?

Researchers believe that migraine is the result of fundamental neurological abnormalities caused by genetic mutations at work in the brain. Investigations of the more rare, familial subtypes of migraine are yielding information about specific genes and what they do, or don't do, to cause the pain of migraine headache. Understanding the cascade of biological events that happen in the brain to cause a migraine, and the mechanisms that underlie these events, will give researchers opportunities to develop and test drugs that could prevent or interrupt a migraine attack.

 

NIH Patient Recruitment for Migraine Clinical Trials

Organizations

American Headache Society Committee for Headache Education (ACHE)
19 Mantua Road
Mt. Royal, NJ   08061
achehq@talley.com
http://www.achenet.org
Tel: 856-423-0043
Fax: 856-423-0082

 
National Headache Foundation
820 N. Orleans
Suite 217
Chicago, IL   60610-3132
info@headaches.org
http://www.headaches.org
Tel: 312-274-2650 888-NHF-5552 (643-5552)
Fax: 312-640-9049

 
Migraine Research Foundation
300 East 75th Street
Suite 3K
New York, NY   10021
info@migraineresearchfoundation.org
http://www.migraineresearchfoundation.org
Tel: 212-249-5402
Fax: 212-249-5405

 
 
Related NINDS Publications and Information
 


 

Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892

 

 

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Reference Links - Add a link

 

 

Clinical Trials - Add a clinical trial

 top
1
Recruiting
Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache
Conditions:
Episodic Cluster Headache;   Chronic Cluster Headache 
Intervention:
Drug: Sumatriptan 4mg Statdose injection 
 
 

 
2
Recruiting
Rhinogenic Headache Improvement After Nasal Operation
Conditions:
Rhinogenic Headache;   Contact Point Headache 
Interventions:
Procedure: Septoplasty;   Procedure: Septoplasty and endoscopic contact point correction 
 
 

 
3
Recruiting
Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction
Condition:
Post Traumatic Headache 
Intervention:
Drug: naratriptan HCl 
 
 

 
4
Recruiting
Galantamine in the Treatment of Post-Traumatic Headache
Conditions:
Post-Traumatic Headache;   Head Trauma,Closed;   Retention Disorders,Cognitive 
Intervention:
Drug: Galantamine 
 
 

 
5
Recruiting
A Randomized Trial to Optimize Discharge From the ED After Treatment for Headache
Conditions:
Migraine;   Tension-Type Headache;   Primary Headache Disorder 
Interventions:
Drug: Sumatriptan 100mg;   Drug: Naproxen 
 
 

 
6
Recruiting
Pediatric Headache Trial
Condition:
Headache 
Interventions:
Behavioral: coping skills training;   Behavioral: headache education;   Drug: amitriptyline 
 
 

 
7
Recruiting
Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache
Condition:
Cervicogenic Headache 
Intervention:
Drug: Botulinum toxin 
 
 

 
8
Recruiting
Epidural Blood Patch on the Resolution of Postdural Puncture Headache (PDPH)
Condition:
Post-Lumbar Puncture Headache 
Interventions:
Other: Epidural Blood Patch;   Other: Epidural Blood Patch;   Other: Epidural Blood Patch 
 
 

 
9
Recruiting
Prophylactic Treatment of Episodic Cluster Headache
Condition:
Cluster Headache 
Intervention:
Drug: candesartan cilexetil (angiotensin II receptor blocker) 
 
 

 
10
Recruiting
Treatment of Acute Migraine Headache in Children
Condition:
Migraine Headache 
Intervention:
Drug: Metoclopramide 
 
 

 
11
Not yet recruiting
Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea
Conditions:
Headache Disorder;   Sleep Disorder;   Obstructive Sleep Apnea 
Intervention:
Device: Continuous positive airway pressure (CPAP) 
 
 

 
12
Recruiting
Detoxification and Treatment of Subjects With Medication Overuse Headache
Condition:
Analgesic Rebound Headache 
Interventions:
Drug: Almotriptan;   Drug: Topiramate 
 
 

 
13
Not yet recruiting
Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache
Condition:
Headache 
Interventions:
Drug: etoricoxib;   Drug: placebo 
 
 

 
14
Recruiting
Juvenile Postlumbar Puncture Headache After Puncture With Needles With Quincke Tip or With Sprotte Tip
Condition:
Headache 
Interventions:
Device: lumbar puncture with Quincke-design needles;   Device: lumbar puncture with Sprotte-design needles 
 
 

 
15
Recruiting
Effect of Small Versus Large Epidural Needles on Postdural Puncture Headache Study
Condition:
Post-Dural Puncture Headache 
Interventions:
Device: 19g Tuohy-type epidural needle, 23g catheter;   Device: => 18g Tuohy-type needle 
 
 

 
16
Recruiting
 

 
17
Recruiting
A RCT on the Efficacy of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Working Community
Conditions:
Migraine;   Tension Type Headache;   Cervical Pain 
Intervention:
Behavioral: Cognitive, Relaxation, Exercise Therapy 
 
 

 
18
Recruiting
Evaluation of Yoga for the Treatment of Pediatric Headaches
Condition:
Headache 
Interventions:
Other: 8 weeks of Iyengar Yoga;   Other: 8 weeks of Iyengar Yoga 
 
 

 
19
Recruiting
Atkins Diet for Difficult-to-Control Headaches in Teenagers
Condition:
Chronic Daily Headache 
Intervention:
Behavioral: Modified Atkins diet 
 
 

 
20
Not yet recruiting
Study in Subjects With Acute Migraines Headaches.
Condition:
Migraine Headache 
Interventions:
Drug: LY2590443;   Drug: Placebo injection;   Drug: Sumatriptan;   Drug: Placebo capsule 
 
 

 
21
Recruiting
A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches
Condition:
Migraine Headache 
Intervention:
Drug: ramelteon 
 
 

 
22
Not yet recruiting
Cluster Headache Cortivazol Injection (CHCI)
Condition:
Cluster Headache 
Interventions:
Drug: ALTIM, cortivazol injections in greater occipital nerve injection;   Drug: PROAMP, subcutaneous serum physiological saline;   Drug: Verapamil 
 
 

 
23
Recruiting
Medication-Overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly?
Condition:
Headache 
Intervention:
Drug: Betablockers or other preventive drugs 
 
 

 
24
Recruiting
An Italian Open-Label Study of Occipital Nerve Stimulation in the Treatment of Chronic Migraine Headache
Condition:
Headache, Migraine 
Intervention:
Device: Neurostimulation 
 
 

 
25
Recruiting
MgSO4 vs Metoclopramide for Headache in Pregnant Women
Condition:
Headache 
Interventions:
Drug: magnesium sulfate;   Drug: metoclopramide 
 
 

 
26
Recruiting
 

 
27
Recruiting
Oral Dexamethasone for Treatment of Migraine
Condition:
Migraine 
Intervention:
Drug: Dexamethasone 
 
 

 
28
Not yet recruiting
Is Paraspinal Intramuscular Ropivacaine Injection an Effective Treatment for Headache in a Pediatric Emergency Department?
Conditions:
Headache;   Migraine 
Interventions:
Drug: Ropivacaine;   Drug: Normal saline 
 
 

 
29
Not yet recruiting
Effect of a New Oral Contraceptive Pill on Hormone Related Symptoms Such as Pelvic Pain and Headache
Conditions:
Oral Contraceptive;   Headache;   Pelvic Pain 
Interventions:
Drug: EV/DNG (Qlaira, BAY86-5027, SH T00658ID);   Drug: Encapsulated Microgynon + Placebo 
 
 

 
30
Recruiting
A Research Study to Examine Cutaneous Allodynia and Cluster Headache
Condition:
Cluster Headache 
Intervention:
Drug: Migranal 
 
 

 
31
Recruiting
Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria
Conditions:
Binocular Dysfunction;   Vertical Heterophoria;   Vision, Binocular;   Vision Disparity 
Interventions:
Device: Lenses containing prismatic correction;   Device: Lenses not containing prismatic correction 
 
 

 
32
Not yet recruiting
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
Conditions:
Migraine;   Chronic Headache 
Intervention:
Drug: Topiramate 
 
 

 
33
Not yet recruiting
Effects of Pretreatment With Ibuprofen in Post-Electroconvulsive Therapy (ECT) Headache
Condition:
Mental Disorders 
Intervention:
Drug: Ibuprofen 
 
 

 
34
Recruiting
Non-Rhinologic Etiologies of Headaches and Facial Pain in Tertiary Care Setting
Conditions:
Headache;   Sinusitis;   Rhinitis;   Facial Pain 
Intervention:
 
 
 

 
35
Recruiting
Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2
Conditions:
Headache;   Migraine;   Vasodilatation 
Interventions:
Drug: Prostacyclin, PGI2;   Drug: Placebo 
 
 

 
36
Recruiting
Prevention Study in Adult Patients Suffering From Migraine Headaches
Condition:
Migraine 
Intervention:
Drug: GSK1838262 
 
 

 
37
Recruiting
 

 
38
Recruiting
Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial
Conditions:
Post Concussive Headache;   Post Concussive Syndrome 
Intervention:
Drug: metoclopramide 
 
 

 
39
Recruiting
The Effect of Nasal Carbon Dioxide (CO2) in the Treatment of Mild Headache in People Who Experience Migraines
Condition:
Migraine 
Interventions:
Drug: Nasal CO2;   Drug: Inactive Placebo 
 
 

 
 
41
Recruiting
Intensive Meditation and Migraines: Effects on Health and Well Being
Condition:
Chronic Daily Headache 
Intervention:
Behavioral: Vipassana Meditation 
 
 

 
42
Recruiting
A Multicenter Study to Evaluate the Efficacy of DR-105 for Menstrually-Related Migraine Headaches
Condition:
Migraine 
Interventions:
Drug: DR-105;   Other: Placebo 
 
 

 
43
Recruiting
Set Point Acupuncture for Migraines Using a Digital Assistant
Condition:
Migraine Headaches 
Intervention:
Procedure: acupuncture 
 
 

 
44
Recruiting
NINDS CRC Chronic Migraine Treatment Trial
Condition:
Chronic Migraine 
Interventions:
Drug: propranolol LA;   Drug: topiramate;   Drug: placebo 
 
 

 
45
Not yet recruiting
A Study to Determine the Effect of Sumatriptan and Naproxen Sodium Combination Tablet, Sumatriptan Tablet, and Naproxen Sodium Tablet on Blood Pressure When Treating Migraine Headaches That Occur During a 6-Month Period
Conditions:
Migraine Headaches;   Migraine With or Without Aura;   Migraine, Acute 
Interventions:
Drug: naproxen sodium tablet;   Drug: sumatriptan and naproxen sodium combination tablet;   Drug: sumatriptan tablet 
 
 

 
46
Not yet recruiting
 

 
47
Not yet recruiting
Study on Migraine and Headache in Epileptic Patients
Condition:
Epilepsy 
Intervention:
 
 
 

 
48
Recruiting
Is Topiramate Effective in Treating Dizziness in Patient's With Migraine-Associated Dizziness
Conditions:
Migraine;   Headache;   Dizziness 
Interventions:
Drug: topiramate;   Drug: lactulose placebo pill 
 
 

 
49
Recruiting
Calcitonin Gene-Related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)
Conditions:
Familial Hemiplegic Migraine;   Migraine With Aura;   Healthy 
Intervention:
Drug: CGRP 
 
 

 
50
Not yet recruiting
Tailored Internet Information Supply for Patients
Condition:
Headache 
Intervention:
Other: Expert system guided tailored information 
 
 
51
Recruiting
Prevention of Menstrual Migraines: Using Frovatriptan or Placebo During Hormone Free Intervals
Conditions:
Migraines;   Bleeding;   Spotting 
Interventions:
Drug: frovatriptan;   Drug: frovatriptan;   Drug: placebo 
 
 

 
52
Recruiting
A Research Study Examining The Use Of Duloxetine In The Prevention Of Migraine Headache
Condition:
Migraine 
Intervention:
Drug: Duloxetine 
 
 

 
53
Recruiting
Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches
Condition:
Refractory Migraine 
Interventions:
Drug: Botulinum toxin A;   Drug: Botulinum toxin A 
 
 

 
54
Recruiting
A Quality of Life Study in Patients With Migraines
Conditions:
Migraine;   Headache;   Depression 
Intervention:
 
 
 

 
55
Not yet recruiting
The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache
Condition:
Episodic Migraine 
Interventions:
Drug: Maxalt;   Drug: placebo pill;   Drug: Maxalt;   Drug: placebo pills;   Drug: Maxalt;   Drug: placebo pills;   Drug: no treatment 
 
 

 
56
Recruiting
Research Study of Greater Occipital Nerve Block As A Treatment For Prolonged Migraine Attacks
Condition:
Migraine 
Intervention:
Drug: 0.5% bupivicaine and 2% lidocaine 
 
 

 
57
Recruiting
 

 
58
Not yet recruiting
Functional MRI (fMRI) in CGRP Induced Migraine
Condition:
Migraine With Out Aura 
Intervention:
Drug: infusion of calcitonin gene related peptide (CGRP) 
 
 

 
59
Recruiting
Correlation of Calcitonin Gene-Related Peptide (CGRP) Levels in Saliva With the Evolution of an Attack of Migraine
Condition:
Headache, Migraine 
Intervention:
Other: subjects usual triptan treatment 
 
 

 
60
Not yet recruiting
Inflammatory Markers in Patients With Active Migraine Headaches
Condition:
Migraine 
Intervention:
 
 
 

 
61
Recruiting
Does Static Ultrasound-Preview Reduce the Incidence of Difficult Lumbar Puncture?
Conditions:
Headache;   Meningitis;   Subarachnoid Hemorrhage 
Intervention:
Procedure: ultrasound of lumbar spine 
 
 

 
62
Recruiting
A Study of a Melatonin Receptor Agonist to Prevent Migraine
Conditions:
Migraine;   Migraine With Aura;   Migraine Without Aura 
Intervention:
Drug: ramelteon 
 
 

 
63
Recruiting
A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine
Condition:
Migraine 
Intervention:
Drug: Migranal 
 
 

 
64
Recruiting
BI 44370 TA in Acute Migraine Attack
Condition:
Migraine Disorders 
Interventions:
Drug: BI 44370 TA;   Drug: Eletriptan 
 
 

 
65
Recruiting
To Compare SH T00658ID to Ortho Tri-Cyclen Lo (US/Canada)
Condition:
Oral Contraceptive 
Interventions:
Drug: Qlaira (BAY86-5027, SH T00658ID);   Drug: Ortho Tri Cyclen Lo 
 
 

 
66
Recruiting
Multi Cervical Unit Measures of Cervical Isometric Strength and Range of Motion: A Pilot Study
Conditions:
Cervicogenic Headache;   Neck Pain;   Whiplash;   Kyphotic and Reversed Cervical Curves 
Intervention:
 
 
 

 
67
Recruiting
Effect of GTN and Diamox Measured by BOLD-Response.
Condition:
Healthy 
Intervention:
Drug: Glyceryl trinitrate, azetazolamide 
 
 

 
68
Recruiting
Efficacy of rTMS in the Treatment of Patients With Migraine
Condition:
Migraine 
Intervention:
Device: Repetitive Transcranial Magnetic Stimulation (rTMS) 
 
 

 
69
Recruiting
The Role of CGRPand Nociceptin in Migraine
Conditions:
Migraine;   Headache 
Intervention:
 
 
 

 
70
Not yet recruiting
The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.
Condition:
Migraine 
Intervention:
Drug: GTN, Diamox 
 
 

 
71
Recruiting
TREXIMA Versus Butalbital-Containing Combination Medications for the Acute Treatment of Migraine in Adults
Condition:
Migraine 
Interventions:
Drug: Trexima;   Drug: Butalbital-containing Combination Medications (BCM);   Drug: butalbital 
 
 

 
72
Recruiting
Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines
Conditions:
Vomiting Syndrome;   Migraines 
Intervention:
 
 
 

 
73
Not yet recruiting
 

 
74
Recruiting
Intravenous Nitroglycerin for Retained Placenta Extraction: a Multicenter Study
Condition:
Retained Placenta 
Interventions:
Drug: nitroglycerine;   Other: NSS 
 
 

 
75
Recruiting
Use of Salt-Water Solution to Improve Symptoms in Concussion
Conditions:
Brain Concussion;   Post-Concussion Symptoms 
Intervention:
Drug: 3% Hypertonic Saline 
 
 

 
76
Recruiting
American Migraine Prevention Study
Condition:
Migraine Disorders 
Intervention:
Behavioral: Serotona Plus and dietary behavior management 
 
 

 
77
Not yet recruiting
 

 
78
Recruiting
Metoclopramide for Acute Migraine: A Dose Finding Study
Condition:
Migraine 
Interventions:
Drug: metoclopramide;   Drug: metoclopramide;   Drug: metoclopramide 
 
 

 
79
Not yet recruiting
Phase 3 Study of MAP0004 in Adult Migraineurs
Condition:
Migraine 
Interventions:
Drug: MAP0004;   Drug: Placebo 
 
 

 
80
Recruiting
Acute Treatment of Multiple Migraines With or Without Aura in Adults
Condition:
Migraine 
Interventions:
Drug: MK0974;   Drug: Comparator : placebo (unspecified) 
 
 

 
81
Recruiting
Study TRX109013, TREXIMA™ (Sumatriptan + Naproxen Sodium) Versus Butalbital-Containing Combination Medications (BCM) for the Acute Treatment of Migraine
Condition:
Migraine 
Interventions:
Drug: Trexima;   Drug: Butalbital-containing Combination Medications (BCM);   Drug: butalbital 
 
 

 
82
Recruiting
Mom: Managing Our Mood, Part of The Family Help Program
Condition:
Postpartum Depression 
Intervention:
Behavioral: Distance Treatment for postpartum depression 
 
 

 
83
Not yet recruiting
Study of Ultrasound of the Eye for Children With Suspected Shunt Failure
Condition:
Hydrocephalus 
Intervention:
Device: Ocular Ultrasound 
 
 

 
84
Recruiting
Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children
Condition:
Vomiting 
Intervention:
Drug: Topiramate 
 
 

 
85
Recruiting
Treatment of Metabolic Alkalosis in Acute Exacerbations of Cystic Fibrosis
Condition:
Cystic Fibrosis 
Intervention:
Drug: Normal saline IV, salt tablets 
 
 

 
86
Not yet recruiting
Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis
Condition:
Carotid Stenosis 
Interventions:
Procedure: carotid artery stenting;   Procedure: carotid endarterectomy 
 
 

 
87
Recruiting
IL-11 in Women With Von Willebrand Disease and Refractory Menorrhagia
Condition:
Von Willebrand Disease 
Intervention:
Drug: Neumega (Oprelvekin, Interleukin 11, IL-11) 
 
 

 
88
Recruiting
IL-11 in Adults With Von Willebrand Disease Undergoing Surgery
Condition:
Von Willebrand Disease 
Intervention:
Drug: Neumega (Oprelvekin, Interleukin 11, IL-11) 
 
 

 
89
Recruiting
Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism
Conditions:
Acetaldehyde Toxicity;   ALDH2 Deficiency;   Altered Ethanol Metabolism 
Intervention:
Drug: fomepizole; 
 
 

 
90
Not yet recruiting
Real-Time Ultrasound Guided Labor Epidural Placement
Condition:
Epidural Anesthesia 
Intervention:
 
 
 

 
91
Recruiting
Visual Discomfort and Reading
Condition:
Visual Fatigue 
Intervention:
Behavioral: Stress on visual discomfort 
 
 

 
92
Recruiting
Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass
Condition:
Cognitive Decline 
Intervention:
Drug: cognitive function 
 
 

 
93
Recruiting
Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
Conditions:
Chronic Fatigue Syndrome;   Fibromyalgia;   Gulf War Illness;   Multiple Chemical Sensitivity;   Interstitial Cystitis;   Irritable Bowel Syndrome 
Intervention:
 
 
 

 
 
95
Recruiting
Prazosin Vibrostimulation Autonomic Dysreflexia and Spinal Cord Injury Study
Condition:
Autonomic Dysreflexia 
Intervention:
Drug: Prazosin HCL 
 
 

 
96
Recruiting
Prevention Of Morbidity In Sickle Cell Disease Pilot Phase
Condition:
Sickle Cell Anaemia 
Intervention:
Device: auto Continuous Positive Airways Pressure (CPAP) with oxygen supplementation 
 
 

 
97
Recruiting
Thymoglobulin Induction Therapy With Minimal Immunosuppression and Evaluation of Allograft Status
Conditions:
Kidney Transplant;   Immunosuppression 
Intervention:
Drug: Tacrolimus 
 
 

 
98
Recruiting
Immunochemotherapy for Metastatic Renal Cell Carcinoma
Condition:
Adenocarcinoma Clear Cell 
Intervention:
Drug: Capecitabine (Xeloda) 
 
 

 
99
Recruiting
Effects From a Mandibular Repositioning Appliance in Patients With Obstructive Sleep Apnea and Snoring
Conditions:
Sleep Apnea Syndromes;   Snoring;   Disorders of Excessive Somnolence 
Intervention:
Device: Mandibular repositioning appliance, adjustable 
 
 

 
100
Recruiting
Carbetocin Versus Syntometrine for the Third Stage of Labour
Condition:
Postpartum Haemorrhage 
Interventions:
Drug: Syntommetrine and Carbetocin;   Drug: Syntommetrine and Carbetocin 
 
 
101
Recruiting
Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis
Condition:
Bacterial Meningitis 
Interventions:
Drug: Glycerol and paracetamol;   Drug: Paracetamol;   Drug: Paracetamol;   Drug: Paracetamol;   Drug: Placebo;   Drug: Paracetamol and glycerol;   Drug: Glycerol 
 
 

 
102
Not yet recruiting
Safety and Immunogenicity of Single Dose Choleragarde® in HIV-Seropositive Adults
Conditions:
Cholera;   Vibrio Infections;   Diarrhea 
Interventions:
Biological: CholeraGarde®;   Biological: Placebo 
 
 

 
103
Recruiting
Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy
Condition:
HIV Infections 
Interventions:
Drug: Metoclopramide;   Drug: Ondansetron;   Drug: Paracetamol;   Drug: Codeine phosphate;   Drug: Ibuprofen 
 
 

 
104
Not yet recruiting
Safety and Immunogenicity of Peru-15 Vaccine When Given With Measles Vaccine in Healthy Indian and Bangladeshi Infants
Conditions:
Cholera;   Diarrhea;   Vibrio Infections 
Interventions:
Biological: Peru-15;   Biological: Placebo 
 
 

 
105
Recruiting
The Long Term Outcomes of Rehabilitation and Drug Treatment for in Urge Urinary Incontinence
Condition:
Urge Urinary Incontinence 
Interventions:
Drug: tolterodine;   Procedure: bladder training;   Procedure: pelvic floor rehabilitation;   Procedure: pelvic floor muscle training 
 
 

 
106
Not yet recruiting
Middle Meatal Bacteriology During Acute Respiratory Infection in Children
Conditions:
Acute Respiratory Infection;   Sinusitis 
Interventions:
Drug: placebo;   Drug: amoxicillin clavulanate acid 
 
 

 
107
Recruiting
Combination Ranibizumab and Bromfenac for Neovascular Age-Related Macular Degeneration
Condition:
Age-Related Macular Degeneration 
Interventions:
Drug: combination ranibizumab + bromfenac;   Drug: ranibizumab injection alone 
 
 

 
108
Recruiting
Pelvic Pain in Women With Endometriosis
Conditions:
Endometriosis;   Pelvic Pain;   Healthy;   Tubal Ligation 
Intervention:
 
 
 

 
109
Not yet recruiting
Home Sleep Testing in Neuromuscular Disease Patients
Condition:
Neuromuscular Disease 
Intervention:
Other: Evaluation for Nocturnal non invasive ventilation 
 
 

 
110
Not yet recruiting
Bridging Study of the Third Generation Killed Whole Cell Oral Cholera Vaccine
Conditions:
Cholera;   Diarrhea 
Interventions:
Biological: Bivalent killed oral cholera vaccine;   Biological: Placebo 
 
 

 
111
Recruiting
Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine
Condition:
Venezuelan Equine Encephalomyelitis 
Intervention:
Biological: VEE TC-83 
 
 

 
112
Recruiting
Lumbar Stenosis Outcomes Research (LUSTOR)
Conditions:
Neurogenic Intermittent Claudication;   Lumbar Spinal Stenosis 
Intervention:
 
 
 

 
113
Recruiting
Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83
Condition:
Venezuelan Equine Encephalomyelitis 
Intervention:
Biological: VEE C-84 
 
 

 
114
Recruiting
 

 
115
Recruiting
An Open Label Non-Randomized Dose Escalating Trial to Assess Safety and Tolerability of Alb-Interferon Alfa 2b Every Two Weeks With Ribavirin Among HIV/HCV Coinfected Individuals
Conditions:
HIV Infections;   HCV 
Interventions:
Drug: Albinterferon;   Drug: Ribavirin;   Drug: Albuferon 
 
 

 
116
Recruiting
Mindfulness vs. Support Groups for Irritable Bowel Syndrome
Condition:
Irritable Bowel Syndrome 
Interventions:
Behavioral: Mindfulness training;   Behavioral: Psycho-educational support group for women with IBS 
 
 

 
117
Recruiting
Treatment of Patients With Cysticercosis With Praziquantel or Albendazole
Condition:
Cysticercosis 
Interventions:
Drug: Praziquantel;   Drug: Albendazole 
 
 

 
118
Recruiting
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study
Conditions:
Cardiovascular Disease;   Coronary Artery Calcification 
Intervention:
 
 
 

 
119
Recruiting
Brain Infusion of Muscimol to Treat Epilepsy
Condition:
Epilepsy 
Intervention:
Drug: Muscimol 
 
 

 
120
Recruiting
Metronidazole for Pulmonary Tuberculosis (South Korea)
Conditions:
Tuberculosis;   Multi-Drug Resistant Tuberculosis 
Interventions:
Drug: Metronidazole;   Procedure: Blood Draw;   Procedure: CT Scan;   Procedure: PET Scan 
 
 

 
121
Recruiting
AMD3100 to Mobilize Stem Cells for Donation
Conditions:
Healthy;   Blood Component Removal 
Intervention:
Drug: AMD3100 
 
 

 
122
Recruiting
An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue
Condition:
Fibromyalgia, Primary 
Interventions:
Drug: armodafinil;   Drug: placebo 
 
 

 
123
Recruiting
Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
Conditions:
Nervous System Malformations;   Arthropathy, Neurogenic;   Urticaria;   Papilledema 
Intervention:
Drug: Anakinra 
 
 

 
124
Recruiting
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension
Condition:
Pulmonary Hypertension 
Interventions:
Drug: Nitric Oxide/INP Pulse Delivery;   Drug: Nitric Oxide/INO Pulse Delivery 
 
 

 
125
Recruiting
The Montefiore Metoclopramide Study
Conditions:
Nausea;   Extrapyramidal Symptoms 
Interventions:
Drug: metoclopramide;   Drug: Diphenhydramine 
 
 

 
126
Recruiting
Phase I Trial of Valproic Acid and Epirubicin in Solid Tumor Malignancies
Condition:
Neoplams, Advanced 
Interventions:
Drug: valproic acid;   Drug: epirubicin;   Drug: 5-fluorouracil;   Drug: Cyclophosphamide. 
 
 

 
127
Recruiting
Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
Condition:
Sinusitis 
Interventions:
Drug: Saline;   Drug: Gentamycin plus saline 
 
 

 
128
Recruiting
 

 
129
Recruiting
Study of the Effect of Repetitive Transcranial Magnetic Stimulation on Language in Patients With Alzheimer's Disease
Condition:
Alzheimer's Disease 
Intervention:
Device: Repetitive Transcranial Magnetic Coil Stimulation (rTMS) 
 
 

 
130
Recruiting
 

 
131
Recruiting
Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)
Conditions:
ALPS;   Hypersplenism;   Lymphadenopathy 
Interventions:
Drug: Valproic Acid;   Procedure: CT Scan;   Procedure: Blood Sample 
 
 

 
132
Recruiting
Natural History and Cause of Neonatal Onset Multisystem Inflammatory Disease
Conditions:
Urticaria;   Arthropathy;   Lymphadenopathy;   Nervous System Anomalies 
Intervention:
 
 
 

 
133
Recruiting
Prevalence of MODIC Changes in Subjects With and Without Low Back Pain
Condition:
Low Back Pain 
Intervention:
 
 
 

 
134
Recruiting
Chronic Hemodialysis Without Systemic Heparinization : a Randomized Study
Condition:
Contra-Indication to the Use of Low Molecular Weight Heparin 
Intervention:
Procedure: Dialysis without systemic heparinization 
 
 

 
135
Not yet recruiting
A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis
Condition:
Migraine 
Interventions:
Drug: rizatriptan benzoate;   Drug: Comparator: placebo 
 
 

 
136
Recruiting
Relative Bioavailibility of a Single Dose of BI 44370 Tablet During and Between Migraine Attacks
Condition:
Migraine Disorders 
Intervention:
Drug: BI 44370 TA tablet 
 
 

 
137
Recruiting
Treatment of Migraine in Patients With Stable Vascular Disease
Conditions:
Migraine Disorders;   Heart Disease;   Cerebrovascular Accident;   TIA (Transient Ischemic Attack);   Vascular Diseases;   Peripheral Vascular Diseases 
Interventions:
Drug: MK0974;   Drug: Comparator: acetaminophen;   Drug: Comparator: Placebo (unspecified) 
 
 

 
138
Recruiting
Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine
Condition:
Migraine 
Interventions:
Drug: propranolol;   Drug: zonisamide;   Drug: topiramate 
 
 

 
139
Recruiting
Migraine and Recurrent Abdominal Pain in Children
Conditions:
Migraine;   Abdominal Pain 
Interventions:
Behavioral: thermal biofeedback;   Behavioral: relaxation training;   Behavioral: cognitive coping skills;   Behavioral: parent education 
 
 

 
140
Recruiting
A Study to Test the Safety and Effectiveness of MK0974 co-Administered With Ibuprofen or Acetaminophen in Patients With Migraines With or Without Aura.
Condition:
Migraine 
Interventions:
Drug: telcagepant;   Drug: Comparator: MK0974 + Ibuprofen;   Drug: Comparator: MK0974 + Acetaminophen;   Drug: Comparator: placebo (unspecified) 
 
 

 
141
Recruiting
 

 
142
Not yet recruiting
Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood
Conditions:
Child;   Migraine 
Interventions:
Drug: metoclopramide and ketoprofen;   Drug: metoclopramide and placebo;   Drug: ketoprofen and placebo 
 
 

 
143
Not yet recruiting
 

 
144
Not yet recruiting
DP-VPA for Migraine Prophylaxis, a Pilot Efficacy Study
Condition:
Migraine 
Interventions:
Drug: DP-VPA;   Drug: DP-VPA Placebo 
 
 

 
145
Recruiting
MK0974 for Migraine Prophylaxis in Patients With Episodic Migraine
Condition:
Migraine 
Interventions:
Drug: MK0974;   Drug: Comparator: Placebo 
 
 

 
146
Recruiting
Does a Migraine Medication Decrease Rotational Motion Sickness in People Suffering From Migraines?
Condition:
Migraine 
Interventions:
Drug: Rizatriptan;   Other: Placebo 
 
 

 
147
Recruiting
 

 
148
Recruiting
Randomized Controlled Trial of Treating Migraine With Acupuncture
Condition:
Migraine 
Intervention:
Other: acupuncture 
 
 

 
149
Recruiting
Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence
Conditions:
Ischemic Stroke;   Patent Foramen Ovale;   Atrial Septal Aneurysm;   Migraine 
Interventions:
Drug: aspirin;   Drug: Antivitamins K;   Device: Devices for PFO closure 
 
 

 
150
Recruiting
Pharmacokinetics and Safety of Intravenous Topiramate in Adult Patients
Conditions:
Epilepsy;   Migraines 
Intervention:
Drug: intravenous topiramate 
 
 


 
151
Recruiting